The principal role of cytochrome p450 in mixed function oxidase reactions includes hydroxylation of various drugs, fatty acids, steroids, pesticides, and carcinogens.
The effects of AAF, p - NF with vitamin A, and a tocopherol on hepatic microsomal cytochrome p450 content in young rats were investigated,
The result is as follows
1) The administrations of AAF, p-NF increased contents of hepatic microsomal cytochrome p - 450.
2) The increased amount of hepatic microsomal cytochrome p450 induced by AAF declined when vitamin A, a -tocopherol and p NF were given.
3) AAF-ringhydroxylation decreased in AAF group, but Nhydroxylation increased, compared to control group.
4) The administration of p NF or p -- NF and AAF increased both ring hydroxylation and N hydroxylation.
5) AAF-ring- hydroxylation increased when AAF was administered with vitamin A, a-tocopherol, and P NF compared to AAF group.
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